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drugs whose blood level is increased or action prolonged by sulfonamides include anticoagulants, anticonvulsants, zidovudine, and methotrexate.
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at doses of 30 mg m or less, methotrexate is generally well absorbed with a mean bioavailability of about 60 .
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taking methotrexate more often, or changing the dose schedule may result in serious side effects.
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