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As with levodopacare should be exercised in administering SINEMET to patients with a history of myocardial infarction who have residual atrialnodalor ventricular arrhythmiasIn such patientscardiac function should be monitored with particular care during the period of initial dosage adjustmentin a facility with provisions for intensive cardiac care.

Standard drugs for Parkinson’s diseaseother than levodopa without a decarboxylase inhibitormay be used concomitantly while SINEMET is being administeredalthough dosage adjustments may be required.

If you experience these effectsdo not drive or operate machinery until these effects have resolved.

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