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When phenytoincarbamazepineor another inducer of hepatic metabolismsuch as rifampicinis added to mirtazapine therapythe mirtazapine dose may have to be increasedIf treatment with such a medicinal product is discontinuedit may be necessary to reduce the mirtazapine dose.

Before taking mirtazapinetell your doctor if you have bipolar disorderliver or kidney diseaseseizuresheart diseasea history of heart attack or strokeor a history of drug abuse or suicidal thoughts.

An interaction between two medications does not always mean that you must stop taking one of themSpeak to your doctor about how any drug interactions are being managed or should be managed.

In managing overdosageconsider the possibility of multiple-drug involvementThe physician should consider contacting a poison control center for additional information on the treatment of any overdoseTelephone numbers for certified poison control centers are listed in the PhysiciansDesk ReferencePDR

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