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Effective nonhormonal contraception must be used by all premenopausal women taking tamoxifen and for approximately two months after discontinuing therapy if they are sexually active.

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You may put on weight when you are taking tamoxifenEating healthily and being more physically active can help to keep you to a healthy weightYour doctor or nurse can give you more advice.

Some side effects can be seriousIf you experience any of the following symptomscontact your doctor immediatelyor call 911Vision problems Lossof appetite Swelling and pain in calf Chest pain Coughing up blood Yellowing of the skin or eyes Unusual bruising or bleeding Fever Blisters Rash Swelling of the eyesfacelipstonguethroathandsarmsfeetanklesor lower legs Wheezing or shortness of breath New breast masses Muscle weakness Restlessness.

AThere are numerous drugs that have possible interactions with tamoxifenThe following is a list of some of the medications that can interact with tamoxifenBlood thinnersCoumadinwarfarinHIV/AIDS medicationsRescriptorNorvirheart rhythm medicationsamiodarone or quinidineantidepressantsWellbutrinCymbaltaProzacimipraminePaxilZoloftKeep in mind that this list is not complete and there are other interactions that may occurIt is always good to check with your doctor or pharmacist about specific medications you may be concerned withso that you can get a more specific answerMegan UeharaPharmD.

You should also tell them if you have any discomfort in the lower tummypelvissuch as pain or pressureThese can be early signs of womb canceralthough they are usually caused by other conditionsIf womb cancer is found earlytreatment can be very successful.

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decreases in platelet counts, usually to 50,000 to 100,000 mm 3 , infrequently lower, have been occasionally reported in patients taking tamoxifen for breast cancer.