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You may have more side effects the longer you take reglan odt and the more reglan odt you take.

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In one study in hypertensive patientsintravenously administered metoclopramide was shown to release catecholamineshencecaution should be exercised when metoclopramide is used in patients with hypertension.

Care should be exercised in administering metoclopramide to neonates since prolonged clearance may produce excessive serum concentrationssee CLINICAL PHARMACOLOGYPharmacokineticsIn additionneonates have reduced levels of NADH-cytochrome b5 reductase whichin combination with the aforementioned pharmacokinetic factorsmake neonates more susceptible to methemoglobinemiasee OVERDOSAGE

Although the risk of developing TD in the general population may be increased among the elderlywomenand diabeticsit is not possible to predict which patients will develop metoclopramide-induced TDBoth the risk of developing TD and the likelihood that TD will become irreversible increase with duration of treatment and total cumulative dose.

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reglan is only approved for short-term use of less than 12 weeks for treatment of gastroesophageal reflux disease gerd , diabetic gastroparesis and delayed gastric emptying.