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ZETIA reduces total-CLDL-CApo Bnon-HDL-Cand TGand increases HDL-C in patients with hyperlipidemiaMaximal to near maximal response is generally achieved within 2 weeks and maintained during chronic therapy.

From this studyit may be concluded that addition of ezetimibe has incremental effects on LDL cholesterol reductionIn patients with a high risk of hepatic insufficiencythe addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatinAlsothe combination of ezetimibe and lovastatin has no greater adverse effects than lovastatin monotherapy7

No dosage adjustment is necessary in patients with mild hepatic impairmentsee WARNINGS AND PRECAUTIONS

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