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Zyloprim reduces the production of uric acid in your bodyUric acid buildup can lead to gout or kidney stones.


Since the excretion of oxipurinol is similar to that of urateuricosuric agentswhich increase the excretion of urateare also likely to increase the excretion of oxipurinol and thus lower the degree of inhibition of xanthine oxidaseThe concomitant administration of uricosuric agents and Zyloprim has been associated with a decrease in the excretion of oxypurineshypoxanthine and xanthineand an increase in urinary uric acid excretion compared with that observed with Zyloprim aloneAlthough clinical evidence to date has not demonstrated renal precipitation of oxypurines in patients either on Zyloprim alone or in combination with uricosuric agentsthe possibility should be kept in mind.

It has been reported that Zyloprim prolongs the half-lifeof the anticoagulantdicumarolThe clinical basis of this drug interaction has not been established but should be noted when Zyloprim is given to patients already on dicumarol therapy.

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