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Patients with severe hepatic impairmentChild-Pugh Cor pre-treatment ASAT or ALAT5 ULN until baseline ASAT/ALAT are stabilised 5 ULN during nevirapine therapy and had recurrence of liver function abnormalities upon readministration of nevirapinesee section 4.4

Serum levels of nevirapine can be reduced by concomitant use of the herbal preparation StJohn’s WortHypericum perforatumThis is due to induction of medicinal product metabolism enzymes and/or transport proteins by StJohn’s Wort.

Discontinue if severe rash or any rash accompanied by constitutional findings occurs.

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Caution should be exercised when co-administering telaprevir with nevirapine.

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