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In patients receiving thiazideshypersensitivity reactions may occur with or without a history of allergy or bronchial asthmaExacerbation or activation of systemic lupus erythematosus has been reported with the use of thiazides.
Hydrochlorothiazide and lisinopril can pass into breast milk and may harm a nursing babyTell your doctor if you are breast-feeding a baby.
Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone systemRAASthrough the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotensionhyperkalaemia and decreased renal functionincluding acute renal failurecompared to the use of a single RAAS-acting agentsee sections 4.34.4 and 5.1
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