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Ondansetron is extensively metabolized in humanswith approximately 5of a radiolabeled dose recovered as the parent compound from the urineThe metabolites are observed in the urineThe primary metabolic pathway is hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation.
Previous versions of the ondansetron labels included a warning about QT interval prolongationThe FDA added a new warning to avoid the use of ondansetron in patients with congenital long QT syndrome because these patients are at particular risk for developing Torsade.
The recommended dosage regimens for adult and pediatric patients are described in Table 1 and Table 2respectively.
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