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Results showed that the onset of noticeable increased iris pigmentation occurred within the first year of treatment for the majority of the patients who developed noticeable increased iris pigmentationPatients continued to show signs of increasing iris pigmentation throughout the five years of the studyObservation of increased iris pigmentation did not affect the incidencenatureor severity of adverse eventsother than increased iris pigmentationrecorded in the studyIOP reduction was similar regardless of the development of increased iris pigmentation during the study.

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The prodrug is well absorbed through the cornea and all drug that enters the aqueous humour is hydrolysed during the passage through the cornea.

There is practically no metabolism of the acid of latanoprost in the eyeThe main metabolism occurs in the liverThe half life in plasma is 17 minutes in manThe main metabolitesthe 1,2-dinor and 1,2,3,4-tetranor metabolitesexert no or only weak biological activity in animal studies and are excreted primarily in the urine.

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